Over-the-counter medications, meals supplements, and varied remedy may perchance well moreover unbiased engage with antiretroviral therapy (ART) in folks living with HIV and be harmful, an industry-subsidized scientific gape from Denmark reports.
“Our uncover about confirms that polypharmacy and being on a protease inhibitor-essentially based routine fabricate higher the risk of doable drug-drug interactions (PDDIs) severely and highlights the importance of questioning folks living with HIV (PLWH) about dietary supplement consumption,” the authors, led by Michaela Tinggaard, MD, Copenhagen University Health center, write in HIV Treatment.
“Doable drug-drug interactions were identical old amongst our uncover about population. Though the scientific significance of the bulk of the identified PDDIs will likely be low, most of them were avoidable through a switch or discontinuation of the comedication, a switch in ART or by spacing remedy,” they add.
Senior author Thomas Benfield, MD, DTMH, DMSc, a professor of infectious diseases on the University of Copenhagen, and colleagues tranquil details on prescription remedy, over-the-counter remedy, and dietary supplements from adults living with HIV who got ART from two outpatient clinics.
The researchers estimated the incidence of non-HIV comedications, and they also worn the University of Liverpool HIV Drug Interactions database to identify doable drug-drug interactions. They evaluated PDDIs and worn logistic regression fashions to study hyperlinks between PDDIs and relevant variables.
The uncover about incorporated 337 folks living with HIV receiving ART. The median age used to be 53 years, 77% of them were male, and 96% were virally suppressed, with HIV-RNA viral load <50 copies/mL.
General, 26% of contributors got 5 or extra comedications, and 56% took dietary supplements.
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In the remedy lists of 52% of sufferers, the authors identified coadministration of instruments that required dose adjustment or monitoring.
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4.5% of sufferers were taking remedy that must not be coadministered.
The researchers detected several factors that independently predicted PDDIs:
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male sex (odds ratio (OR), 1.9; 95% CI, 1.0 – 3.4)
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being on a protease inhibitor (OR, 4.3; 95% CI, 1.9 – 9.7)
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receiving 5 or extra comedications (OR, 3.3; 95% CI, 1.5 – 7.2)
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