A mix of extremely high intravenous dosages of vitamin C and a diet plan that simulates fasting might be a reliable way to deal with an aggressive kind of cancer, a research study in mice recommends. Unlike the majority of cancer treatments, it is unlikely to be harmful for healthy tissue.
In the 1970 s, when the Nobel prizewinning chemist Linus Pauling initially proposed that high dosages of intravenous vitamin C might deal with cancer, people dismissed his idea as quackery.
But recent research study recommends that he was onto something. A small 2017 medical trial, for example, found that high doses of vitamin C in combination with radiotherapy and chemotherapy are well-tolerated and might extend the survival of people with brain cancer.
Larger medical trials examining the combination of high dosage vitamin C with these standard cancer treatments are currently underway.
A study in mice now suggests that a diet that mimics the effects of fasting can boost the capability of vitamin C to treat colorectal cancer while preventing the requirement for chemotherapy or radiation treatment.
The research study, which appears in Nature Communications, likewise provides hints about how high dosages of vitamin C may work and under what situations.
In the quantities that a healthy diet plan provides, vitamin C is an anti-oxidant, scavenging highly reactive complimentary radicals in tissues.
Injecting the vitamin straight into the blood stream, nevertheless, leads to high tissue concentrations, at which it ends up being a “pro-oxidant,” triggering the development of complimentary radicals such as hydrogen peroxide.
In a cancer cell, free radicals can damage large particles, including proteins, lipids, and DNA, causing cell death.
Some research study recommends that an aggressive kind of cancer that has mutations in a gene called KRAS is susceptible to totally free extreme damage from high dosages of vitamin C, although the results have actually been mixed.
KRAS– mutant cancers are resistant to most other cancer therapies, and people with these cancers have a lower survival rate. Researchers quote that these mutations happen in around one-quarter of all human cancers and about 40%of all colorectal cancers.
Integrating vitamin C with chemotherapy seems to yield the best lead to KRAS– mutant cancers. This treatment damages healthy and malignant tissue alike, which can trigger extreme unfavorable impacts
Researchers from the University of Southern California (USC) in Los Angeles and the IFOM Cancer Institute in Milan, Italy, set out t