A lab study has discovered that the asthma drug salbutamol avoids the development of tangles of fibrous protein that are a hallmark of Alzheimer’s illness. The next action will be to evaluate the drug in animal designs of the illness.
About 50 million people worldwide have dementia, and every year, there are almost 10 million new cases, according to the World Health Organization (WHO)
They keep in mind that the most typical form of dementia is Alzheimer’s illness, which accounts for 60–70%of all cases.
In the United States, the National Institute on Aging quote that more than 5.5 million people have Alzheimer’s disease. The majority of them are over 65 years of age.
The illness is a neurological condition in which the death of brain cells results in progressive memory loss and cognitive decline.
While existing drug treatments help reduce the symptoms of Alzheimer’s illness and improve individuals’s lifestyle, they neither slow its progression nor remedy it.
The brains of individuals with the condition include unique plaques between afferent neuron, as well as clumps of fibers referred to as neurofibrillary tangles inside the cells.
The plaques consist of a protein called beta-amyloid, while another protein called tau makes up the tangles.
After clinical trials found that drugs that clear beta-amyloid from the brain stopped working to slow the illness’s development, tries to find a treatment have actually shifted to tau.
Researchers at Lancaster University in the United Kingdom believe that tau could be a more appealing drug target for Alzheimer’s illness. They point to previous research study, which discovered that in the absence of the tau neurofibrillary tangles, beta-amyloid does not seem to damage afferent neuron.
Also, the variety of tangles in the brain appears to be a better indication of the seriousness of the disease than the number of amyloid plaques.
In healthy brain cells, tau proteins help support the internal network of microscopic tubes, or “microtubules,” that transports nutrients and other particles around afferent neuron.
In Alzheimer’s illness, these tau molecules break away from the microtubules and begin to sti