Scientists stumbled on solid static magnetic fields can safely serve terror and despair indicators in mice. They deem that top static magnetic fields obtain the aptitude to be an antidepressant remedy at some point soon.
Scientists recently conducted a series of experiences to take a look at the biosafety and neurobehavioral effects of 33.0 Tesla excessive static magnetic fields (SMF) the use of the self-designed biological study platform of Actual High Magnetic Field Facility (SHMFF). The experiments had been performed by Prof. Xin Zhang’s team on the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.
They, for the first time, reported the biosafety of 30 Tesla stage SMF and the neurobehavioral effects of 20 Tesla and 30 Tesla stage SMF on healthy mice within the Journal of Magnetic Resonance Imaging and European Radiology.
In newest years, ultra-excessive field magnetic resonance imaging (MRI) has developed suddenly attributable to its main assist of excessive imaging decision. 7 Tesla MRI has been clinically approved and 21.1 Tesla MRI has been efficiently historical in rodents. Nonetheless, experiences on the biosafety of excessive magnetic fields above 20 Tesla are gathered scarce, and there is gathered a gap in relevant experiences above 30 Tesla.
Essentially based mostly on the previous biosafety stare of three.5-23.0 Tesla SMF, Xin Zhang’s community further increased the magnetic field intensity and shortened the publicity time. Healthy C57BL/6J mice had been exposed to 7.0-33.0 Tesla SMF for one hour.
Experiments utilized on SHMFF. Credit: Yue Lyu
After publicity, all mice had been mechanically fed for 2 months. Excluding for a few metabolic and liver and hepatorenal feature indicators tormented by the magnetic field, the total blood count and organ coefficient on histomorphology of critical organs had been not severely affected, Many of the mice remained contained within the trendy reference differ.
Meanwhile, behavioral exams confirmed that top SMF alleviated terror and improved social and spatial memory in mice within two months after publicity.
Besides, behavioral experiences of healthy mice exposed to a 3.5-23.0 Tesla magnetic field for 2 hours additionally stumbled on improved neurocognitive effects, which will be linked to increased calcium/calmodulin-dependent protein kinase II expression within the mouse hippocampus.
Zhang’s community further stumbled on that 7 Tesla SMF would possibly per chance possibly well effectively serve indicators of depressed mice. These results not only provide famous safety recordsdata for the enchancment of ultra-excessive MRI, however would possibly per chance possibly well also gift that top SMF has the aptitude to be a future antidepressant remedy.
Reference: “Brief- and lengthy-duration of time effects of three.5–23.0 Tesla ultra-excessive magnetic fields on mice behaviour” by Md Hasanuzzaman Khan, Xinfeng Huang, Xiaofei Tian, Changjie Ouyang, Dongmei Wang, Shuang Feng, Jutao Chen, Tian Xue, Jin Bao and Xin Zhang, 16 March 2022, European Radiology.
DOI: 10.1007/s00330-022-08677-8
This stare modified into supported by the National Key Review & Construction Program of Ministry of Science and Technology, the National Pure Science Foundation of China, the President’s Fund of Hefei Institutes of Physical Science, and plenty of others.