Summary
Background
Observational research studies have suggested that sped up surgery is connected with improved.
outcomes in clients with a hip fracture. The HIP ATTACK trial examined whether sped up.
surgical treatment could reduce death and major complications.
Techniques
HIP ATTACK was an international, randomised, regulated trial done at 69 medical facilities.
in 17 nations. Clients with a hip fracture that needed surgical treatment and were aged.
45 years or older were qualified. Research study personnel arbitrarily assigned patients (1:1).
through a main computerised randomisation system using randomly varying block sizes.
to either sped up surgical treatment (objective of surgical treatment within 6 h of medical diagnosis) or standard.
care. The coprimary results were death and a composite of major complications.
( ie, mortality and non-fatal myocardial infarction, stroke, venous thromboembolism,.
sepsis, pneumonia, lethal bleeding, and significant bleeding) at 90 days after.
randomisation. Clients, health-care companies, and study personnel knew treatment.
assignment, but outcome adjudicators were masked to treatment allocation. Clients.
were analysed according to the intention-to-treat concept. This study is registered.
at.
ClinicalTrials.gov(.
NCT02027896).
Findings
Between March 14, 2014, and May 24, 2019, 27701 clients were screened, of whom7780
were eligible. 2970 of these were registered and randomly appointed to receive accelerated.
surgery (n =-LRB- ) or standard care (n =-LRB- ). The average time from hip fracture diagnosis.
to surgery was 6 h (IQR 4– 9) in the accelerated-surgery group and 24 h (10–42) in.
the standard-care group (p