— Mucosal damage seen on upper endoscopy connected with 76% greater Parkinson’s danger
by Judy George, Deputy Managing Editor, MedPage Today
September 6, 2024
- Upper GI mucosal damage was connected to a 76% greater threat of subsequent Parkinson’s illness.
- The retrospective research study followed GI clients for almost 15 years.
- The findings support literature recommending that, for some clients, Parkinson’s illness might come from the gut.
Intestinal (GI) mucosal damage seen on upper endoscopy was connected to a 76% greater danger of a subsequent Parkinson’s illness medical diagnosis, a retrospective associate research study revealed.
Over a typical follow-up of almost 15 years, individuals with upper GI mucosal damage were most likely than those without it to establish Parkinson’s illness (HR 1.76, 95% CI 1.11-2.51, P=0.01), reported Trisha Pasricha, MD, MPH, of Beth Israel Deaconess Medical Center in Boston, and co-authors in JAMA Network Open
Mucosal damage was specified as disintegrations, esophagitis, ulcers, or peptic injury on esophagogastroduodenoscopy (EGD) or pathology reports.
At standard, clients with mucosal damage were most likely to have a history of Helicobacter pylori infection, proton-pump inhibitor usage, persistent nonsteroidal anti-inflammatory substance abuse, gastroesophageal reflux illness, cigarette smoking, irregularity, and dysphagia, the scientists stated
The research study is among a number of connecting Parkinson’s illness with earlier systemic or gut swelling.
“There has actually been a growing body of literature supporting the concept that, a minimum of for some clients, Parkinson’s illness might come from the gut,” Pasricha informed MedPage Today
“We understand that numerous clients with Parkinson’s illness experience signs like irregularity or difficulty swallowing years, or perhaps years, before they get motor signs. And research studies have actually discovered alpha-synuclein deposition throughout the intestinal system,” she stated.
Anecdotal proof appeared to recommend a greater connection in between peptic ulcers and Parkinson’s illness, Pasricha explained. “Here, we revealed for the very first time that a history of upper intestinal mucosal damage, which we verified by taking a look at endoscopic and pathology reports, was connected with a 76% higher threat